Traditional approaches to analyzing episodes of patient care in the ICU examine features on presentation and outcomes on discharge, collapsing the numerous events that happen during a patient’s stay and ignoring intercurrent ICU complications or interventions. With CarpeDiem, we aimed to examine clinical features on a per-day basis as done during the common practice of daily physician rounds. The Successful Clinical Response in Pneumonia Therapy (SCRIPT) CarpeDiem Dataset features 12,495 patient-ICU-days from 585 patients enrolled in the SCRIPT study between June 2018 and March 2022, all of whom were critically ill patients on mechanical ventilation suspected of having pneumonia who underwent a bronchoalveolar lavage as part of routine clinical care. Each patient has demographics, pneumonia episode information as adjudicated by a panel of critical care physicians, outcomes, and 44 clinical parameters for which data are present including vital signs, laboratory parameters, vasopressor dosing, and mechanical support devices. Data have been deidentified per Health Insurance Portability and Accountability Act (HIPAA) Safe Harbor rules. This dataset combines expert clinician adjudication with per-day granular information to provide a unique tool to examine the clinical courses of critically ill patients with pneumonia.